James M Trauer 1, Peter J Dodd 2, M Gabriela M Gomes 3,4, Gabriela B Gomez 5, Rein MGJ Houben 6,7, Emma S McBryde 8, Yayehirad A Melsew 1, Nicolas A Menzies 9, Nimalan Arinaminpathy 10, Sourya Shrestha 11, David W Dowdy 11. The Importance of Heterogeneity to the Epidemiology of Tuberculosis. Clinical infectious diseases https://doi.org/10.1186/s12879-018-3388-y
Although less well-recognised than for other infectious diseases, heterogeneity is a defining feature of TB epidemiology. To advance toward TB elimination, this heterogeneity must be better understood and addressed. Drivers of heterogeneity in TB epidemiology act at the level of the infectious host, organism, susceptible host, environment and distal determinants. These effects may be amplified by social mixing patterns, while the variable latent period between infection and disease may mask heterogeneity in transmission. Reliance on notified cases may lead to misidentification of the most affected groups, as case detection is often poorest where prevalence is highest. Assuming average rates apply across diverse groups and ignoring the effects of cohort selection may result in misunderstanding of the epidemic and the anticipated effects of control measures. Given this substantial heterogeneity, interventions targeting high-risk groups based on location, social determinants or comorbidities could improve efficiency, but raise ethical and equity considerations.
1.School of Public Health and Preventive Medicine, Monash University, Australia